We want to kill tumor cells, but we don’t want to ..

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We want to kill tumor cells, but we don’t want to harm the nontumor cells, and at the moment, that’s still a challenge. | #succinimide

We want to kill tumor cells, but we don’t want to harm the nontumor cells, and at the moment, that’s still a challenge.

We want to kill tumor cells, but we don’t want to harm the nontumor cells, and at the moment, that’s still a challenge.

With this in mind, Seattle Genetics’ new generation of linkers incorporate a primary amine adjacent to the maleimide, which promotes a much faster hydrolysis reaction. “Using this linker, we can prepare ADCs in which the succinimide is completely hydrolyzed during the conjugation proce

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